Molecular machines

It has recently become possible to synthesize molecules that function like mechanical devices, such as switches, motors, brakes, and even small elevators. Such man-made molecular machines might be considered as nanoscale versions of their macroscopic analogues. However, many well-known macroscopic concepts no longer apply at a molecular level. For instance, the concept of viscous friction becomes meaningless: the friction that a molecular machine experiences is caused by molecules that have the roughly same size as the machine, and the time scale of the machine's motion is similar to that of the molecules causing the friction. Continuum mechanics clearly cannot be used to describe the dynamics of molecular machines, and new approaches have to be developed. To obtain a better understanding of the physics and chemistry of molecular machines, experiments that directly probe their motion are essential, and the insights obtained from such experiments should be important for potential applications.

We use time-resolved and two-dimensional vibrational spectroscopy to study structure and motion in molecular machines at the atomic level. The molecular machines we study are based on rotaxanes (see picture above). Rotaxanes are mechanically interlocked molecules consisting of a macrocyclic ring (yellow in picture) kept on a linear thread by means of bulky "stoppers" (grey in picture). Rotaxane-based molecular machines include light-driven molecular motors and pistons.

For more information see:

Molecular machines investigated with 2DIR spectroscopy
Unravelling the operation mechanism of a molecular machine