Biologically Sensitive Field Effect Devices

Dr. Pedro Estrela
Polysilicon TFT Group, University of Cambridge - Engineering Department
pme22@cam.ac.uk


Biochip technology is in high demand in many areas, including medical diagnostics and treatment monitoring, genomics and proteomics, food and environment control, forensics and biodefence. In order to ensure that biochips are made widely accessible to these applications, a key requirement is that they are fabricated on inexpensive substrates and incorporated into low-cost portable instrumentation. One way this may be achieved is to exploit mature fabrication technologies based on field effect devices. New detection mechanisms have been developed using field effect devices such as metal-oxide-semiconductor diodes and thin film transistors. Examples will be given on the application of such solid state devices to blood/urine analysis as well as the detection of DNA and protein interactions.

References:
1. P. Estrela et al., Biosens. Bioelectron. 20 (2005) 1580
2. F. Yan, P. Estrela et al., Appl. Phys. Lett. 86 (2005) 053901